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Bioinformatic analysis of long-lasting transcriptional and translational changes in the basolateral amygdala following acute stress

Fig 2

Acute restraint stress induces long last proteomic changes in the BLC.

(A) A summary of the global proteomics profile of the BLC in mice that underwent a single acute restraint session 30 days prior. (B) The top 25 most differentially regulated proteins in the BLC of stressed mice and their log2 fold change (Log2FC) values. (C+D) Ingenuity Pathway Analysis of the global proteomics profile identified the top 10 most significant canonical pathways (C) and functional annotations (D) of the gene list. Upregulated pathways are shown in green and downregulated in orange, with the number of molecules belonging to each pathway indicated to the right. (E) Representative images of western blot validation of Ube2d3 protein. On the left are the total protein stain for normalization and the image of Ube2d3. On the right is the quantification of the western blot data.

Fig 2

doi: https://doi.org/10.1371/journal.pone.0209846.g002