Quantitative systems pharmacology of interferon alpha administration: A multi-scale approach
Fig 10
Parameter scan for the initial concentration of IFNA Receptor2.
PBPK/PD simulation (lines) of concentration time profile for A) IFN-α in venous blood plasma and the experimental blood plasma profile (solid circles) of IFN-α in humans. B) IRF9 mRNAc response to different initial concentrations of IFN-α Receptor2 that are 0.0005, 0.002, 0.003, 0.0015 and 0.001 μmol/l. The reference concentration in the initial simulation (dashed black line) for Receptor2 was 0.5 μmol/l.