Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose
Fig 2
Quantitative protein-level results overview.
a, Heatmap of 276 proteins that show at least one statistically-significant diet-induced change (q-value < 0.05, fold-change > 1.5). Values in grey are not significant at this threshold. Each diet is compared to the appropriate 2- or 10-week control, except the last column shows the direct comparison of 10-week glucose divided by 10-week HFD. b, Proteins showing altered abundance (small circles) between the 10-week glucose cohort and the 10-week HFD cohort in the last column of (a) were analyzed for GO and KEGG ontology term enrichment (large circles). Blue indicates lower abundance in 10-week glucose group compared to 10-week HFD group (or higher abundance in the 10-week HFD group than the 10-week Glucose group) and red indicates higher abundance in the 10-week glucose / 10-week HFD comparison (or lower abundance in the 10-week HFD group than the 10-week glucose group).