TAK-071, a muscarinic M1 receptor positive allosteric modulator, attenuates scopolamine-induced quantitative electroencephalogram power spectral changes in cynomolgus monkeys
Fig 4
TAK-071 at 0.3–3 mg/kg suppressed the scopolamine-induced qEEG changes.
Scopolamine (25 μg/kg, s.c.) and TAK-071 (0.3–3 mg/kg, p.o.) were simultaneously administered to cynomolgus monkeys. After treatment with drugs or vehicle, (A) alpha, (B) theta, and (C) delta power bands of qEEG spectra were measured from 30 to 240 min. Results represent mean ± SEM of AUC between 30 and 210 min after treatment for 3–4 monkeys in each group. *P ≤ 0.05 versus vehicle-treated group by paired t-test. #P ≤ 0.05 versus scopolamine-treated group by paired t-test. AUC, area under the curve; p.o., oral administration; qEEG, quantitative electroencephalogram; SEM, standard error of the mean; s.c., subcutaneous administration.