Temporal clustering analysis of endothelial cell gene expression following exposure to a conventional radiotherapy dose fraction using Gaussian process clustering
Fig 10
Interaction networks of the five node genes and “Radiation”.
(A) Protein network of the 5 node genes BIRC5, CXCL8, CXCL10, CXCL12 and PTGS2 and the term “Radiation” as treatment was obtained using the Pathway Studio software. (B) Protein network of the 5 node genes were linked to the regulating cell processes using the subnetwork enrichment analysis module of Pathway Studio searching for proteins regulating cell processes. Fisher’s exact test p-values were calculated by the Pathway Studio software and are indicated for each statistically significantly identified cell process (see also S7 Table for the full list results). Ranks based on the p-values are indicated for each cell process (#).