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Identifying feasible operating regimes for early T-cell recognition: The speed, energy, accuracy trade-off in kinetic proofreading and adaptive sorting

Fig 3

Effect of changing γ on the speed, accuracy, and energy consumption of a KPR based-circuit.

(a) Accuracy versus mean first-passage time (1/speed) and (b) dissipation (power consumption) versus mean first-passage time (1/speed) when the the phosphorylation rate ϕ is varied for different choices of γ = 0, 0.1, 10−1.5, 10−3. For all curves, b/ϕ = 0.01, τs = 1, and τf = 10. The squares indicate locations corresponding to parameters with a minimal error rate (see Fig 2 and Table 1 for full definition of parameters).

Fig 3

doi: https://doi.org/10.1371/journal.pone.0202331.g003