Identifying feasible operating regimes for early T-cell recognition: The speed, energy, accuracy trade-off in kinetic proofreading and adaptive sorting
Fig 1
An overview of T cell activation.
A T-cell is activated when a ligand-binds a TCR receptor long enough to be phosphorylated n = 4 times. In the “life-time dogma” picture considered in this paper, foreign ligands bind more strongly to the receptor than self ligands with average disassociation times of foreign and self ligands given by τf = 10s and τs = 1s respectively. If the ligand disassociates from the receptor, the receptor is dephosphorlyated and the whole process must begin anew.