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PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition

Fig 2

PIK3CAmut potentiate proliferation and migration in vitro.

MTS assays showed that PIK3CAWT and all PIK3CAmut decreased doubling times of NHA (A), but not NHARAS (B) (*, P≤0.02 vs parental, S5A and S5B Fig). PIK3CAmut, except C90Y, decreased doubling times compared to PIK3CAWT NHA (ǂ, P≤0.03). Growth rates were analyzed by comparing k values. Error bars are 95% confidence intervals. PIK3CAWT and PIK3CAmut, except C90Y, increased migration of both NHA (C) and NHARAS (D) (*, P≤0.04, S5C and S5D Fig). E542K and H1047R also potentiated migration compared to PIK3CAWT NHA and NHARAS (ǂ, P≤0.005). Fold changes in doubling times and migration rates relative to parental and PIK3CAWT lines are shown as heatmaps.

Fig 2

doi: https://doi.org/10.1371/journal.pone.0200014.g002