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A receptor tyrosine kinase ROR1 inhibitor (KAN0439834) induced significant apoptosis of pancreatic cells which was enhanced by erlotinib and ibrutinib

Fig 8

Effects of KAN0439834 and anti-ROR1 mAb on ROR1 associated signaling molecules in the pancreatic cancer cell line PaCa-2.

Western blots showed inhibition of ROR1, LRP6, SRC, PI3Kδ, AKT, mTOR and CREB phosphorylation after incubation (2 h) with (A) KAN0439834 (500 nM) and (B) anti-ROR1 mAb (10 μg/ml). (+) treated cells and (-) untreated cells.

Fig 8

doi: https://doi.org/10.1371/journal.pone.0198038.g008