Inflammatory signatures distinguish metabolic health in African American women with obesity
Fig 3
Six-cluster signature in BWHS subjects taking metformin or NSAIDs.
Patterns of sixteen cytokines by signatures assigned with the multi-label classification algorithm. The algorithm used the profiles of cytokines discovered in the original BWHS set of sixty two subjects to infer the most likely signature of fifty eight other subjects, who had been excluded from the first analysis because they were taking medications. The six signatures are very similar to those calculated for Fig 2 subjects, who were not taking medications. Only the distribution of CCL22 in Cluster 3 differed significantly (P-value = 0.003) from the distribution of CCL22 in patients assigned to the same Cluster 3 in the discovery set (Fig 2). For all other signatures, the difference in distributions of individual cytokines by cluster was tested using t-test and no other comparison reached statistical significance after Bonferroni correction for multiple testing (P < 0.003).