The hypoxia inducible factor/erythropoietin (EPO)/EPO receptor pathway is disturbed in a rat model of chronic kidney disease related anemia
Fig 4
a-c: Bone marrow (BM) EPO receptor (EPO-R) decreases in uremic anemia rats.
BM EPO-R protein (depicted as percentage of actin-corrected concentration) is unchanged in 7 day-bled rats Vs controls (Fig. 4a). Contrary to that BM EPO-R protein decreases in uremic (4 weeks after 5/6 nephrectomy) rats (Fig. 4b). BM EPO-R mRNA (Fig. 4c) shows a similar pattern. * p<0.01 Vs C. 6–8 rats were used in each group.