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Bilateral carotid artery stenosis causes unexpected early changes in brain extracellular matrix and blood-brain barrier integrity in mice

Fig 7

Decreased number of anastomoses in BCAS-treated mice.

A) Representative cortical images (1x) of Di I perfused brains of sham and BCAS-treated (day 14 and 30) mice. Magnified image below to show detail. White circle is one example of an anastomosis. B) Quantification of the number of anastomoses between the MCA and ACA and the MCA and PCA in sham and BCAS-treated (day 14 and 30) mice. N = 5–8 **p < 0.01 ***p < 0.001 MCA: middle cerebral artery, ACA: anterior cerebral artery, PCA: posterior cerebral artery.

Fig 7

doi: https://doi.org/10.1371/journal.pone.0195765.g007