The serine protease homolog spheroide is involved in sensing of pathogenic Gram-positive bacteria
Fig 3
Sphe is involved in danger signal cascade.
drosomycin expression 24 hours PI, normalized to rp49 after immune challenge with E. faecalis (* ctrl (spheΔ11) vs. spheΔ104 p<0.0381, ** spheΔ104vs. spheΔ104;;grasshrd p<0.0329) (A), after immune challenge with wild type and protease-deficient bacteria (comparison) (B) with protease-deficient strain of E. faecalis TX5128 (D) or with E. faecium (F); Survival rate after immune challenge with protease-deficient strain of E. faecalis TX5128 (**ctrl vs psh4 p<0.0031. There are no explanations for this slight phenotype) (C), or with E. faecium (E).