Computational model of interictal discharges triggered by interneurons
Fig 3
Experiment reveals a shift of GABA reversal potential.
A: IPSCs were recorded in control and epileptic solution with pharmacological blockade of glutamatergic synaptic currents at different holding potentials. B: left, the I-V relationships were plotted for the peak currents shown in A. Right, the statistical estimations of VGABA reveal reliable shift from -58 in control up to -50 mV in pro-epileptic solution. Experimental data points are fitted with the Goldman-Hodgkin-Katz equation as in [14].