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Thymoquinone ameliorates diabetic phenotype in Diet-Induced Obesity mice via activation of SIRT-1-dependent pathways

Fig 5

Effects of TQ on serum cholesterol.

(A) Total cholesterol serum concentration. (B) HDL cholesterol serum concentration. (C) LDL/VLDL cholesterol serum concentration. p≤0.05 when comparing (+) HFD and LFD, (*) HFD + TQ and HFD using independent t-tests. Results are means ± SEM (n = 6–7 mice per treatment group). LFD: low fat diet, HFD: high fat diet, TQ: thymoquinone, LDL: low-density lipoprotein, HDL: high-density lipoprotein, VLDL: very-low-density lipoprotein.

Fig 5

doi: https://doi.org/10.1371/journal.pone.0185374.g005