Extranodal spread of primary and secondary metastatic nodes: The dominant risk factor of survival in patients with head and neck squamous cell carcinoma
Fig 5
Influence of pre-existing 1st met and history of ND in the same neck side of 2nd met.
A, B, Kaplan-Meier analysis in 95 HNSCC patients with 2nd mets. The number of cases at risk (no. at risk) at each time point (0–120 months) was provided in B. p <0.003 for patient groups with (neck with 1st met) vs. without (neck without 1st met) preceding 1st met and ND in the same neck side of 2nd met (log-rank test). C, Correlations between ENS in 2nd mets and 1st met and/or ND history in the same neck sides of 79 HNSCC patients with 2nd met. ENS-positive rates were calculated for patient groups with different profiles of 1st met and ND history, including 1st met (+)/ND (+), 1st met (-)/ND (+), and 1st met (-)/ND (-). p = 0.008 for different groups (Cochran-Armitage test).