Evolutionary analysis and interaction prediction for protein-protein interaction network in geometric space
Fig 1
An example to show the principle of our algorithm.
(a) Ground-truth network; (b) Maximum connected component; (c) Minimum spanning tree (training set); (d) Evolved network (dash lines are elementary predictions based on evolutionary analysis); (e) Distance matrix based on shortest path in MST; (f) Distance matrix based on evolutionary distance; (g) Coordinates in geometric space; (h) Euclidean distances in geometric space and corresponding confidence scores.