Salsalate ameliorates metabolic disturbances by reducing inflammation in spontaneously hypertensive rats expressing human C-reactive protein and by activating brown adipose tissue in nontransgenic controls
Fig 5
Validation of directional expression of genes identified by SPIA using quantitative real-time PCR for six transcripts in livers isolated from SHR-CRP rats versus SHR controls treated either with placebo or salsalate.
The expression of selected genes was normalised relative to the expression of the peptidylprolyl isomerase A (Ppia) (cyclophilin) gene, which served as an internal control. * denotes p<0.05 and p<0.001.