In vivo efficacy of the AKT inhibitor ARQ 092 in Noonan Syndrome with multiple lentigines-associated hypertrophic cardiomyopathy
Fig 3
SHP2Y279C/+ hearts treated with ARQ 092 have improved cardiac function.
Echocardiography was used to analyze the cardiac function in SHP2+/+ and SHP2Y279C/+ mice, either vehicle or ARQ 092 treated for 4 weeks, starting at 12 weeks of age. (A) LVIDd, (B) LVPWd, (C) SV (D) IVSs, (E) IVSd, and (F) FS% parameters were measured Data represent mean ± SEM. *P < 0.05, where P values were derived from from 2-way ANOVA on ranked data, with Bonferroni post hoc test when ANOVA was significant; n = 3–7 mice/group. LVIDd, left ventricular chamber dimension in diastole; LVPWd, left ventricular posterior wall thickness in diastole; SV, stroke volume; IVSs, intraventricular septal diameter in systole; IVSd, intraventricular septal diameter in diastole; FS%, fractional shortening.