skn-1 is required for interneuron sensory integration and foraging behavior in Caenorhabditis elegans
Fig 2
skn-1 regulates sensory integration in C. elegans.
(A) skn-1(zu135) worms showed wild type chemotaxis to optimal doses of volatile compounds and reduced migration to sodium chloride. Chemotaxis indexes were determined at the following odorant concentrations: 1% benzaldehyde (BA); 0.1% butanone (BU); 1% diacetyl (DA). Sodium chloride chemotaxis was tested on a 5 mM gradient. The percentages of animals remaining at the origin in presence of NaCl (B), butanone (C), or the indicated concentrations of benzaldehyde (D), are shown. (E) skn-1 food-leaving behavior is impaired in the presence of very low local concentrations of food (OP50 E. coli). (F) skn-1 chemotaxis toward BA is significantly decreased and dwelling behavior enhanced in the presence of known concentrations of bacterial lawn. Data are mean and S.E.M. of 3–6 trials performed in triplicate. *p<0.05; **p<0.01; ***p<0.001 versus N2 (Student’s t-test).