Fetuin-A deficiency protects mice from Experimental Autoimmune Encephalomyelitis (EAE) and correlates with altered innate immune response
Fig 6
Dendritic and monocyte cell populations are increased in spleens from EAE mice lacking Fetuin-A.
(A) Representative flow cytometry plots of dendritic cells positive for CD11c and CD11b from spleens of WT and FAKO EAE mice on day 14. (B) Quantitation of dendritic cell populations shown in (A). (C) Percentages of CD11c+ dendritic cells positive for CD80 and MHCII from WT and FAKO EAE mice on day 14. (D) Representative flow cytometry plots of CD11b+/CD14+ monocytes in spleens of WT and FAKO EAE mice on day 14. (E) Representative flow cytometry plots of CD14+ monocytes positive for CD11b and Ly6C. CD11b+/Ly6Chi population is gated. (F) Quantitation of monocyte populations shown in (E) and (F). Values represent mean ± standard deviation from a representative experiment, n = 4 mice per group. *, p<0.05; **, p<0.01; ***, p<0.001.