Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine posttraumatic osteoarthritis
Fig 5
hCol1 reduces MMP13 levels in articular cartilage of mice following MLI.
3 weeks post-injury (Sham or MLI), knee joints were harvested from mice and hypertrophic chondrocytes were analyzed by immunohistochemistry of MMP13 and ColX. Representative sagittal sections depict (A) MMP13 and (B) ColX stained chondrocytes (brown) with cell nuclei counterstained with hematoxylin (blue). Yellow dasted lines highlight the tide mark, separating calcified cartilage from uncalcified cartilage. Joint structures are labeled (F = femur, M = meniscus), and the black scale bar depicts 100μm.