Melatonin protects rats from radiotherapy-induced small intestine toxicity
Fig 2
Immunohistochemical staining of Ki-67 and ZO-1.
Immunohistochemical staining of the proliferation marker Ki-67 (A) and of the tight junctions protein zonula occludens 1 (ZO-1) (C) in rat small intestine from non-irradiated rats (control) and irradiated rats treated with vehicle (IR) or melatonin gel (IR + aMT). The right panels show details at higher magnification. Scale bar = 100 μm and 50 μm in the left and right panels, respectively. (B, D) Quantification of the staining in A and C; n = 4 per group. Data are expressed as mean ± s.e.m. ***P < 0.001 vs. control and ###P < 0.001 vs. IR.