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Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure

Fig 3

Richness, diversity, and UniFrac distances of gut microbiota in younger and older patients with heart failure.

Chao1-estimated operational taxonomic unit (OTU) number (A) and Shannon index (B) of gut microbiota samples obtained from younger and older patients with heart failure (HF-Y and HF-O, respectively). Unweighted UniFrac analysis (C, D) and weighted UniFrac analysis (E, F) of gut microbiota samples obtained from HF-Y and HF-O. Principal Coordinate Analysis (PCoA) of UniFrac distances between gut microbial communities of the individuals (C, E), and UniFrac distances between gut microbial communities of the individuals within each group and between the two groups (D, F). Data are presented as mean ± SEM. NS, not significant. ** p < 0.01.

Fig 3

doi: https://doi.org/10.1371/journal.pone.0174099.g003