Early mutation bursts in colorectal tumors
Fig 5
Summary of posterior distributions for different sequencing depths.
The first column and second column show the mean and standard deviation of each parameter’s posterior distribution for the 300 simulated tumors respectively. The top row is the summary of for mutation rate before gland formation. The middle row is for the mutation rate after gland formation while the third row shows the results for the asymmetric division rate. The black dots, red dots and green dots represent the results when the mean sequencing depths are 20, 40, and 80 respectively, per single gland. We see little improvement of parameter estimation with even higher sequencing depths. The other generating parameter values used were: NCSC = 32, T3 = 100, and v = 1.1m for the negative binomial distribution used to generate sequencing depth.