CD24 expression does not affect dopamine neuronal survival in a mouse model of Parkinson's disease
Fig 2
CD24 protein expression pattern in the adult mouse brain.
(A) CD24 expression in the mouse forebrain at two levels of the striatum. (B) Coronal sections of the midbrain at the level of the caudal end of the mammillary bodies (MM). TH staining on the left section indicates the location of the dopamine neurons of the SNpc. CD24 labels DA neurons in the SNpc, as well as the lateral posterior thalamic nucleus (LPMC), superior colliculus (SC), and nuclei surrounding the medial geniculate (MG). (C) Immunofluorescent staining of TH and CD24 indicates some localisation in the SNpc. Dashed line box highlighting area of the high magnification image in panel D. (D) CD24 staining on TH+ DA neurons in the SNpc, labelling dendritic fibres projecting down into the substantia nigra pars reticulata (SNpr). (E) TH and CD24 staining in the hindbrain where the LC is labelled by both. Co-ordinates in the right hand corners of panels A, B & E indicate the location of the coronal plane relative to bregma. The scale bar in panel A represents 800μm in panel A&E, 500μm in panel B, 200μm in panel C, and 50μm in panel D.