Clinical Significance of Programmed Death Ligand‑1 and Intra-Tumoral CD8+ T Lymphocytes in Ovarian Carcinosarcoma
Fig 2
Immunohistochemical staining for programmed death ligand 1 (PD-L1) in intraepithelial and mesenchymal tumor tissue.
A-C: Haematoxylin and eosin-prepared samples of OCS tissues containing both carcinomatous (☆) and mesenchymal components (ϒ). The homologous subtype is composed of high-grade undifferentiated round cell or spindle cell sarcomatous proliferation (tissue native to the ovary, △). Heterologous carcinosarcoma may show cartilaginous differentiation (tissue not native to the ovary, arrow). D-F: Representative immunohistochemical staining for PD-L1 expression in OCS. Samples were divided into three groups according to the intensity of PD-L1 expression: weak (D), moderate (E), and strong (F) staining of PD-L1. Tissue of placenta (G) was used as positive control for PD-L1 expression (at x400 magnification).