Knockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells
Fig 2
Knockdown of HSPA9 increases expression of the TP53 target genes p21 and BAX in CD34+ cells.
(A) Representative immunoblot of p21 and BAX following knockdown of HSPA9 in CD34+ cells. (B) Gene Set Enrichment Analysis (GSEA) enrichment score plot for 13 annotated p21-inhibited genes. Individual genes in the gene set are represented by a black vertical bar in the middle of the plot.