A Novel Positron Emission Tomography (PET) Approach to Monitor Cardiac Metabolic Pathway Remodeling in Response to Sunitinib Malate
Fig 1
Physiological effects of sunitinib in two rodent models.
Effects of sunitinib treatment on MAP (A, n = 9/group) and LVEF (B, n = 13/group) in female Balb/CJ mice. D-E) Effect of sunitinib treatment on systolic blood pressure (C), LVEF (D) and heart rate (E) in female Sprague-Dawley rats (n = 6/group, Significant difference between groups (unpaired t-test, *p<0.05 **p<0.01 ***p<0.001), Significant change from pre-treatment values (paired t-test, †p<0.05 ††p<0.01 †††p<0.001). Error bars = SEM)