Drug Repositioning for Alzheimer’s Disease Based on Systematic ‘omics’ Data Mining
Fig 2
AD related protein-metabolite network.
1179 protein-metabolite interactions were indicated from the HMDB database. The zoomed-in inset shows that acetylcholinesterase (P22303), a known anti-AD target, interacts with 2 AD-related metabolites (Choline and Acetylcholine). The nodes with yellow color represent metabolites that were altered in AD patients, the nodes with purple color represent proteins that linked to AD associated metabolites, and the nodes with green color represent proteins that linked to ≥2 AD associated metabolites.