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Self-Organizing Global Gene Expression Regulated through Criticality: Mechanism of the Cell-Fate Change

Fig 14

Local and global perturbations in self-organizing genome-wide expression: The kinetic energy self-flux dynamics (y-axis) for the CM of a critical state (see section VI) exhibit clear energy-dissipative behavior.

Notably, the results show the occurrence of global and local perturbations of self-organization. Pulse-like global perturbations show a transition from IN to OUT net kinetic energy flux or vice versa (IN-OUT switching) in more than one critical state: at 15-20min, HRG; at 12-18h, DMSO; and at 2-4h (significant) and 12-18h, atRA. In contrast, local perturbation is observed in the EGF response for up to 36h: there is only a marked response in the super-critical state, and almost no response in the other states (i.e., the dynamics of the CM of critical states are localized around their average: Fig 11). The results suggest that the global and local perturbations differentiate MCF-7 cell fates, whereas global perturbations drive the state change in HL-60 cells (see section I).

Fig 14

doi: https://doi.org/10.1371/journal.pone.0167912.g014