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The Effects of Dietary Macronutrient Balance on Skin Structure in Aging Male and Female Mice

Fig 3

Macronutrients and male skin structure.

Response surfaces showing the association between macronutrient intake (protein, carbohydrate and fat in kJ/d) and male skin structure. (a-c) epidermis thickness (μm) increases with high protein or carbohydrate intake, (d-f) dermis thickness (μm) increases with high protein intake, (g-i) subcutaneous fat thickness (μm) increases with high carbohydrate or high fat intake. For each 2D slice, the third factor is at its median. Response surfaces are similar to heat maps, red indicates maximum values, blue indicates minimum values. The black lines are isolines, like contour lines on a topographical map, and indicate areas of equality for the response variable e.g. in (a) isolines join areas of equal epidermis thickness. The red lines are nutritional rails and indicate the ratio of macronutrients that maximizes each response. (See also S2 Table).

Fig 3

doi: https://doi.org/10.1371/journal.pone.0166175.g003