Arachidonic Acid Metabolite 19(S)-HETE Induces Vasorelaxation and Platelet Inhibition by Activating Prostacyclin (IP) Receptor
Fig 6
Platelet-inhibitory effects of 19(S)-HETE are mediated by IP receptor.
(A-D) Effect of 19(S)-HETE (3 μM), cicaprost (1 μM) and sodium nitroprusside (SNP) (1 mM) pretreatment of platelets on aggregation of platelets isolated from wild-type (Ptgir+/+) and IP-receptor-deficient mice (Ptgir-/-) induced by 0.1 U/ml thrombin. Shown are representative aggregation traces of at least 3 independently performed experiments.