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The Level of IgA Antibodies to Endothelial Cells Correlates with Histological Evidence of Disease Activity in Patients with Lupus Nephritis

Fig 3

Correlation between AECA titer and histological evidence of active lesions defined by ISN/RPS classification in LN patients.

A. The level of IgG-AECA did not correlate with active lesions, but the level of IgA-AECA for HUVEC did correlate with histological evidence of active lesions in LN patients (P < 0.001). *A: active lesion defined by ISN/RPS 2003 classification in LN. B. ROC curve analysis of IgA-AECA to differentiate LN patients with histological evidence of active lesions from those without. AUC was 0.84. The sensitivity as a diagnostic test for histological evidence of active lesions in LN patients was 0.92, with specificity of 0.70. AUC, area under curve.

Fig 3

doi: https://doi.org/10.1371/journal.pone.0163085.g003