Forced Trefoil Factor Family Peptide 3 (TFF3) Expression Reduces Growth, Viability, and Tumorigenicity of Human Retinoblastoma Cell Lines
Fig 2
Effects of stable, lentiviral TFF3 overexpression on RB cell viability, proliferation and growth.
WST-1 assays (A), BrdU stains (B) and growth curves of TFF3 overexpressing (TFF3) Y-79 (C), WERI-Rb1 (D), RBL-13 (E) and RBL-15 (F) versus control cells (ctr) transduced with lentiviral control particles revealed that forced TFF3 expression leads to a significant reduction in cell viability, proliferation and cell growth rates, the latter with an overall P < 0.001. Values are means of at least 3 independent experiments ± SEM. **P < 0.01; ***P < 0.001; ns = no statistical differences compared to the control group calculated by Student`s t-test.