High-Resolution Identification of Specificity Determining Positions in the LacI Protein Family Using Ensembles of Sub-Sampled Alignments
Fig 3
SDP results for the highest scoring positions by SDPPred and Speer.
Each position receiving a top-20 score from at least one of the comparative methods, SDPPred and Speer, are shown. Ensemble score for SDPPred is the average ranking. Ensemble score for Speer is the average z-score. See Methods for details on SDPPred and Speer ensemble averages. Position scores are shown for SDPPred, Speer, and GroupSim. Group-specific scores for each specificity group at the corresponding position are also shown. Marker size and color correspond to score according to color bars. Note that top 7.5% of scores make up the vast majority of color scale for each method. For column-wise scoring methods the 27th highest score corresponds to the 92.5th percentile, since 27 ÷ 360 = 0.075, or 7.5%.