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Systems Analysis of Early Host Gene Expression Provides Clues for Transient Mycobacterium avium ssp avium vs. Persistent Mycobacterium avium ssp paratuberculosis Intestinal Infections

Fig 3

Heatmap of pathway scores of a side-by-side comparison (by time point) between MAP vs PBS versus MAA vs PBS.

The heatmap compares MAP significantly perturbed pathways to the MAA condition. The selection of pathways was based on those that were found significant (DBGGA zscore ≥ 2.24) for the MAP condition at 30 minutes post infection. Red indicates activation and green indicates repression. The gradient in color indicates magnitude of perturbation (i.e., higher |zscore|).

Fig 3

doi: https://doi.org/10.1371/journal.pone.0161946.g003