Protein Co-Expression Analysis as a Strategy to Complement a Standard Quantitative Proteomics Approach: Case of a Glioblastoma Multiforme Study
Fig 5
Visualisation of the brown module using a network generated in Cytoscape.
The global network is shown in Fig 5A. The main large cluster identified by the MCODE application, being coloured in green and the most interconnected (‘hub’) proteins shown in purple. This main cluster extracted from the brown module is shown in Fig 5B and other secondary clusters identified by MCODE are also shown (Fig 5C, 5E and 5F). In Fig 5B, 5C, 5E and 5F, proteins highlighted in red are associated with a defined GO term assigned by GOrilla. The main cluster as shown in Fig 5B was analysed using a hierarchical clustering approach based on protein intensity across the tumour (Tu) and the control (Ct) samples and is shown in Fig 5D. Five sub-clusters were identified and further analysed using Toppcluster.