Prenatal Cocaine Exposure Upregulates BDNF-TrkB Signaling
Fig 8
Prenatal cocaine exposure altered 145-KDa TrkB conformation in hippocampi (top) and PFCX (bottom).
The conformational states of the immunopurified 145-KDa TrkB was analyzed by separating on pH3-10 isoelectric focusing gels and then Western blotted with anti-TrkB. Blots were quantified by densitometric scanning. Data are means ± s.e.m. of the pI 6.1 and pI 6.9. n = 5 (3 males and 2 females). p < 0.01 compared to respective protein in the saline-treated group.