Diurnal Variations of Human Circulating Cell-Free Micro-RNA
Fig 3
A, Heatmap showing overrepresented Reactome pathways. For each miRNA all strong targets (defined by miRTarBase) was used for GO analysis using gProfileR. Only miRNAs where target genes were significantly overrepresented in one or more pathways are shown. Colors indicate p-value with red colors being associated with lower p-values. Non-significant matches were all assigned the value 0.05. The color bar on top of the plot indicates groups belonging into 5 time-point specific expression groups (group 1: red, group 2: blue, group 3: green, group 4: black, group 5: pink). B, MAPK pathway targets. Strongly binding predicted MAPK pathway targets of significant rhythmic miRNAs of the present study are colored red.