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Experimental Design for Stochastic Models of Nonlinear Signaling Pathways Using an Interval-Wise Linear Noise Approximation and State Estimation

Fig 14

Testing the approximation for different observations horizons.

P-values for Kolmogorov-Smirnov tests whether the approximation is fulfilled for different observation horizons; left panel shows results for benchmark and right panel for MSS. Each color stands for one of the 50 data sets. Test is performed with the true parameter θ = (0.5, 0.0025, 0.3).

Fig 14

doi: https://doi.org/10.1371/journal.pone.0159902.g014