Fibulin-5 Regulates Angiopoietin-1/Tie-2 Receptor Signaling in Endothelial Cells
Fig 1
A: Solid-phase binding assays showing the interactions between Ang-1, TIE-2, and Fibulin-5. Tropoelastin was used as a positive control. Ang-1, TIE-2, and tropoelastin were used as immobilized ligands and Fibulin-5 as the soluble ligand. Fibulin-5 showed a strong binding for tropoelastin but no significant binding was observed to Ang-1 or TIE-2. N = 5 per group. B: Solid-phase binding assays showing the interactions between Ang-1, TIE-2, and Fibulin-5. TIE-2 and Fibulin-5 were used as immobilized ligands and Ang-1 protein as the soluble ligand. Ang-1 showed a strong binding to TIE-2 but no significant binding to Fibulin-5. N = 5 per group.