The Response of microRNAs to Solar UVR in Skin-Resident Melanocytes Differs between Melanoma Patients and Healthy Persons
Fig 2
MicroRNAs differentially expressed in melanocytes of skin after exposure to ssUVR.
(a and b) A color-coded heat map representations of UV-miRNAs in melanocytes commonly expressed in melanoma patients or healthy individuals. The map in (a) ranks each miRNA by their fold-change (RQ), beginning with those having the most negative RQ value (top) to the highest negative RQ value (bottom), whereas the map in (b) ranks each from the most negative to the most positive RQ value. The color bars at the top of (a) and (b) represent the normalized intensity of down-regulated or up-regulated UV-miRNAs with the shaded blue corresponding to a decrease in expression and that of shaded red to an increase in expression. The left margin shows the representative miRNAs and the bottom of the columns show each individual sample. MicroRNAs in the heat map of (a) and which match those previously identified in melanoma tissue are marked by a star. (c) An identical set of UV-miRNAs in the melanocytes of patients or healthy persons is effected differently by ssUVR. The y-axis indicates relative gene expression, and the whisker bars indicate the standard error of the mean. MicroRNAs that match those previously identified in melanoma tissue are marked by a star.