Anti-Inflammatory and Antinociceptive Properties of Flavonoids from the Fruits of Black Mulberry (Morus nigra L.)
Fig 4
Effects of TF on mediator production in the blood of KM male mice.
The KM male mice were pre-treated p.o. with normal saline (control 20 mL/kg), normal saline (model 20 mL/kg), aspirin (Asp 75 mg/20 mL/kg), dexamethasone (Dex 3 mg/20 mL/kg), and total flavonoids (TF) extracts (TF-50: 50 mg/20 mL/kg; and TF-100: 100 mg/20 mL/kg). One hour after the last drug dose, each group except the control group were treated with xylene and formalin to induce inflammation and nociception. The control group was treated with normal saline. The data were shown as mean ± SD (n = 10). *p < 0.05 and **p < 0.01 significantly different from the model group.