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Association between DNA Methylation in Whole Blood and Measures of Glucose Metabolism: KORA F4 Study

Fig 2

Genome-wide associations between methylation and (a) fasting glucose, (b) 2-hour glucose, (c) fasting insulin, (d) HOMA-IR, after adjustment for sex, age, and estimated white blood cell proportions (model 1). Results are plotted for each chromosome (excluding the sex chromosomes) (x-axis) against the–log (unadjusted p-value) (y-axis). The Benjamini-Hochberg method was used as correction for multiple testing. The dotted line marks the significance threshold. Red dots: methylation levels of these CpG sites are associated with these phenotypes in model 1; turquois dots: methylation levels of these CpG sites are significantly associated with the phenotype after additional adjustment for BMI (model 2); blue dots: methylation levels of these CpG sites are significantly associated with the phenotype in both adjustment models.

Fig 2

doi: https://doi.org/10.1371/journal.pone.0152314.g002