Factors that Affect Pancreatic Islet Cell Autophagy in Adult Rats: Evaluation of a Calorie-Restricted Diet and a High-Fat Diet
Fig 2
Effects of dietary intervention on islet cell apoptosis (AI and c-caspase-3) in adult SD rats (n = 5 for each group).
TUNEL staining (A) and c-caspase-3(B) in the ND, HFD and CRD groups at 0, 8 and 16 weeks (bars represent 125 μm), respectively. Apoptosis index (C) and MOD analysis of c-caspase-3 (D) in the pancreatic islets of adult SD rats fed a ND, HFD, or CRD. #: vs. 0 weeks, ▲: CRD/HFD vs. ND, ★CRD vs. HFD. P<0.05. 0 weeks (14 months old), 8 weeks (16 months old), and 16 weeks (18 months old).