In Vivo Deletion of the Cebpa +37 kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis
Fig 9
Model for the Role of C/EBPα During Hematopoiesis.
In this model, HSC give rise to lymphoid-myeloid progenitors (LMP) and to MEP, MEP generate megakaryocyte (Meg) and erythroid (E) progenitors, and GMP give rise to granulocytic progenitors (G) in the presence of high-level C/EBPα and to monocytic progenitors (Mo) in the presence of low-level C/EBPα. CLP give rise to T and B cell progenitors in the absence and to bipotent B/Mo progenitors in the presence of C/EBPα. The latter diverge to B cell or monocytic progenitors, again correlated with and potentially guided by loss or retention of C/EBPα.