Synaptosomal Mitochondrial Dysfunction in 5xFAD Mouse Model of Alzheimer's Disease
Fig 5
Increased Parkin translocation and LC3BII recruitment in synaptosomal mitochondria from 5xFAD mice.
Synaptosomal mitochondria and cortices from young and old nonTg and 5xFAD mice were subjected to the immunoblots for the levels of synaptosomal mitochondrial recruited Parkin (A1), the levels of Parkin in cortex (A2), and the levels of synaptosomal mitochondria-recruited LC3BII (B). The left panels show the analyzed results in fold increase and the right panels are representative immunoblot bands. Mitochondrial TOM40 and β-actin were used as the loading controls for mitochondrial fractions and cortex homogenate, respectively. N = 4–6 mice per group.