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Comparative Genomic Analysis of Mannheimia haemolytica from Bovine Sources

Fig 5

Pan-genome and core genome of 21 M. haemolytica isolates.

For both the pan-genome (grey) and the core genome (black), the number of genes is plotted as a function of the number n of strains sequentially added. Panel A: serotype 1 strains, n = 8. Panel B: serotype 6 strains, n = 7. Panel C: serotype 2 strains, n = 6. The curve for the S1 pan-genome represents the least-squares fit for the function y = AxB + C with the best fit obtained with a correlation r2 = 0.999 for A = 572.81 ± 4.45, B = 0.79, C = 2104.32 ± 19.12. The curve for the S1 core genome represents the least-squares fit for the function y = AeBx + C with the best fit obtained with a correlation r2 = 0.976 for A = 1549.09 ± 90.55, B = -0.81, C = 1964.34 ± 14.87. The curve for the S6 pan-genome represents the least-squares fit for the function y = AxB + C with the best fit obtained with a correlation r2 = 0.999 for A = 652.62 ± 8.5, B = 0.73, C = 1942.33 ± 25.16. The curve for the S6 core genome represents the least-squares fit for the function y = AeBx + C with the best fit obtained with a correlation r2 = 0.983 for A = 1601.51 ± 92.41, B = -0.74, C = 1806.86 ± 19.97. The curve for the S2 pan-genome represents the least-squares fit for the function y = AxB + C with the best fit obtained with a correlation r2 = 0.999 for A = 944.93 ± 10.83, B = 0.65, C = 1527.44 ± 23.12. The curve for the S2 core genome represents the least-squares fit for the function y = AeBx + C with the best fit obtained with a correlation r2 = 0.988 for A = 2123.13 ± 68.56, B = -0.88, C = 1579.86 ± 5.88.

Fig 5

doi: https://doi.org/10.1371/journal.pone.0149520.g005