Ketamine Metabolites Enantioselectively Decrease Intracellular D-Serine Concentrations in PC-12 Cells
Table 1
The concentration-dependent decrease of intracellular D-Ser concentrations produced by incubation of PC-12 cells with the enantiomers of ketamine (Ket) and its major metabolites expressed as IC50 values and percent (%) maximum decrease from vehicle-treated PC-12 cells.
The effect of the configuration at the chiral centers on the magnitude of the IC50 value represented as the enantioselectivity factor α is derived by IC50(2R isomer)/IC50(2S isomer). The values for (R)-Ket were obtained from [17] and ‘NA’ indicates that (S)-Ket increases intracellular D-Ser concentrations [17]. Results are expressed as means ± SD, n = 3 independent experiments.